The desire to which it refers is one that turns into an obsession and seeks control of the desired object or person, when you wind up controlled by your own desires.
Not all wishes are negative.
The third (anatta). You can stop suffering. If you neutralise and expel your desires, you will no longer suffer. The fewer the desires, the lesser the pain; the more obsessive desires, the higher the dissatisfaction. By eliminating all your ego, you will reach the Nirvana.
The ‘place’ that Buddha proposes to us is close to what it means to be at peace with oneself, that is, peace of mind, to reach a state of serenity and inner peace.
The fourth. Follow the middle road, the Noble Eightfold Path. Avoid extremes, show compassion and love for the world, maintain ethical conduct, practise meditation and seek a certain detachment from reality and an understanding of its true nature, i.e., seek wisdom.
Ridding yourself of your ego is the way of avoiding ‘I’ and ‘mine’, thus reducing your instinct for self-protection, give up your properties and even, in the end, give up life itself.